Projects
This page lists the projects that form part of our first wave of pilot users for OpenSAFELY.
All projects are reviewed by NHS England to ensure they support relevant research and planning activities in response to the COVID-19 emergency; have a favourable ethical opinion (for research) or appropriate sensor sponsorship (for service evaluation or audit); and all users adhere to the OpenSAFELY ways of working.
The pilot users have also written the summaries of their project below. Their emails are shared if you would like to contact them to understand more about their project.
Legal background and consultation summary
OpenSAFELY projects numbered 1-155 were approved during the COVID-19 pandemic under legal powers issued by the Secretary of State: Regulation 3(4) of the Health Service (Control of Patient Information) Regulations 2002 – COPI Regulations.
Under this emergency legal power, the Type 1 Opt-out [archived here] (which a patient can register with their GP surgery to prevent their GP data from being shared outside the GP practice for planning or research purposes) was not required to be upheld for research and planning purposes in the pandemic. Therefore, for projects 1-155 a patient who had registered a Type 1 Opt-out could have had their GP health information used (anonymously) in these projects.
In June 2023, the legal basis for OpenSAFELY’s operation changed [archived here] from the emergency COPI Regulations to the COVID-19 Public Health Directions 2020. Under this Direction, the Type 1 Opt-out will be upheld for all new projects (after 155).
However, in June 2023, 97 projects were still ongoing, and these projects were given a special transitional arrangement to allow researchers to complete their work, which means the projects may include patient data from individuals with a Type 1 Opt-out. These projects are listed in appendix 3 of the OpenSAFELY Service DPIA [archived here].
As part of the transition to the new legal basis, NHS England consulted many organisations, including representatives of patients, the ICO, the National Data Guardian for Health and Social Care, and the BMA and RCGP (see the Data Provision Notice [archived here] for the full list).
Separately, the BMA and RCGP have written to NHS England outlining their support for the OpenSAFELY platform to be extended to all research, service evaluation, clinical audit and health surveillance. Privacy group medConfidential has also stated their support for OpenSAFELY.
See the NHS England OpenSAFELY COVID-19 Service privacy notice for more information about the service.
List of archived projects
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Project #175: Implications of metformin for Long COVID
Research project run by University of Bristol.
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Project #174: ECHO – Evaluation of Covid-19 vaccine Histories using OpenSAFELY
Service evaluation project run by University of Oxford.
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Project #173: Analysis of the ‘Pharmacy First’ element in the plan to restore access to primary care following the impact of COVID-19
Service evaluation project run by University of Oxford.
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Project #172: Impact and inequalities of winter pressures in primary care: providing the evidence base for mitigation strategies
Research project run by The London School of Hygiene and Tropical Medicine, University of Oxford and University of Bristol.
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Project #171: Healthcare needs for people with chronic kidney disease in the COVID-19 era (Project continuation of approved project no 137)
Research, and service evaluation project run by London School of Hygiene & Tropical Medicine.
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Project #170: Effectiveness of sotrovimab/molnupiravir use vs non-use (Project continuation of approved project no 115)
Research project run by London School of Hygiene and Tropical Medicine.
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Project #169: Long-term kidney outcomes after SARS-CoV-2 infection (Project continuation of approved project no 78)
Research project run by London School of Hygiene & Tropical Medicine.
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Project #168: Digital access to primary care for older people during COVID (Project continuation of approved project no 152)
Research project run by University of Manchester and Newcastle University.
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Project #167: Evaluating the UK ‘shielding’ policy during the COVID-19 pandemic (Project continuation of approved project no 150)
Research project run by London School of Hygiene and Tropical Medicine.
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Project #166: The impact of COVID-19 on pregnancy treatment pathways and outcomes (Project continuation of approved project no 148)
Research project run by The University of Manchester.
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Project #165: Comparison of risk factors for hospitalizations and death from winter infections (Project continuation of approved project no 143)
Research project run by University of Bristol, University of Cambridge and University of Oxford.
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Project #164: Risk factors for COVID-19 disease progression in immunocompromised populations (Project continuation of approved project no 139)
Research project run by London School of Hygiene & Tropical Medicine.
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Project #163: Explaining the differential severity of COVID-19 between Indians in India and the UK (Project continuation of approved project no 101)
Research project run by London School of Hygiene & Tropical Medicine.
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Project #162: Management of Early Inflammatory Arthritis during the COVID-19 Pandemic (Project continuation of approved project no 100)
Service evaluation project run by King’s College London.
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Project #161: COVID-19 Collateral (Project continuation of approved project no 95)
Research project run by The London School of Hygiene and Tropical Medicine.
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Project #160: Coverage, effectiveness and safety of neutralising monoclonal antibodies or antivirals for non-hospitalised patients with COVID-19 (Project continuation of approved project no 91)
Service evaluation project run by University of Oxford.
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Project #159: Risk factors and prediction models for Long COVID (Project continuation of approved project no 31)
Research project run by University of Plymouth / University of Bristol.
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Project #158: The effect of COVID-19 on pancreatic cancer diagnosis and care (Project continuation of approved project no 27)
Service evaluation project run by University of Surrey.
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Project #157: Investigating the effectiveness of the COVID-19 vaccination programme in the UK (Project continuation of approved project no 22)
Research project run by University of Bristol.
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Project #156: Investigating events following SARS-CoV-2 infection (Project continuation of approved project no 12)
Research project run by University of Bristol.
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Project #155: The effect of Long COVID on Quality Adjusted Life Years using OpenPROMPT
Research project run by The London School of Hygiene and Tropical Medicine.
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Project #154: Validation of ISARIC / SUS / PHOSP data for COVID-related hospital admissions
Research project run by University of Oxford.
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Project #153: What was the impact of COVID-19 on mortality related to venous thromboembolism in England?
Audit, and service evaluation project run by NHS England.
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Project #152: Digital access to primary care for older people during COVID
Research project run by University of Manchester and Newcastle University.
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Project #151: Venous thromboembolism and cardiovascular events in inflammatory rheumatic diseases
Research project run by King’s College London.
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Project #150: Evaluating the UK ‘shielding’ policy during the COVID-19 pandemic
Research project run by London School of Hygiene and Tropical Medicine.
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Project #149: Descriptive cohort analysis of Long COVID and vaccination status
Research project run by London School of Hygiene & Tropical Medicine.
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Project #148: The impact of COVID-19 on pregnancy treatment pathways and outcomes
Research project run by The University of Manchester.
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Project #147: Winter pressures in primary care in the context of COVID-19 recovery
Service evaluation project run by University of Oxford.
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Project #146: Scarlet fever and invasive group A strep cases during the COVID-19 pandemic
Service evaluation project run by University of Oxford.