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Project #88:
Impact of reduced kidney function, dialysis and transplantation on vaccination efficacy against COVID19

  • Type: Audit / Service Evaluation
  • Topic areas: COVID transmission/prevalence/non-pharmaceutical prevention, Risk from COVID (short term) [e.g. hospitalisation/death], COVID vaccine effectiveness/safety

A previous analysis of breakthrough infections has found that people on renal replacement therapy (dialysis and transplantation) appear to be more susceptible to breakthrough infections with COVID19 even if they were previously vaccinated.

The aim of this project is to use combined data on kidney function and the requirement of renal replacement therapy from both primary care and UK Renal Registry data as well as hospital codes to quantify how impaired kidney function and modalities of renal replacement therapy modify the risk of breakthrough infections after vaccination.

We will also quantify the protective impact using third as well as booster-vaccinations compared to not having received booster vaccines.

The output will be a research paper and inform national vaccination policy.

  • Study leads: Dorothea NitschLaurie Tomlinson
  • Organisation: University of Oxford, London School of Hygiene and Tropical Medicine and UK Kidney Association