Paper information
- Authors
-
- Ellen Thompson,
- Dylan Williams,
- Alex Walker,
- Ruth Mitchell,
- Claire Niedzwiedz,
- Tiffany Yang,
- Charlotte Huggins,
- Alex Kwong,
- Richard Silverwood,
- Giorgio Di Gessa,
- Ruth Bowyer,
- Kate Northstone,
- Bo Hou,
- Michael Green,
- Brian Dodgeon,
- Katie Doores,
- Emma Duncan,
- Frances Williams,
- Andrew Steptoe,
- David Porteous,
- Rosemary McEachan,
- Laurie Tomlinson,
- Ben Goldacre,
- Praveetha Patalay,
- George Ploubidis,
- Srinivasa Vittal Katikireddi,
- Kate Tilling,
- Christopher Rentsch,
- Nicholas Timpson,
- Nishi Chaturvedi,
- Claire Steves
- Citation
- Thompson, E.J., Williams, D.M., Walker, A.J. et al. Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records. Nat Commun 13, 3528 (2022). https://doi.org/10.1038/s41467-022-30836-0
- Categories
Abstract
The frequency of, and risk factors for, long COVID are unclear among community-based individuals with a history of COVID-19. To elucidate the burden and possible causes of long COVID in the community, we coordinated analyses of survey data from 6907 individuals with self-reported COVID-19 from 10 UK longitudinal study (LS) samples and 1.1 million individuals with COVID-19 diagnostic codes in electronic healthcare records (EHR) collected by spring 2021. Proportions of presumed COVID-19 cases in LS reporting any symptoms for 12+ weeks ranged from 7.8% and 17% (with 1.2 to 4.8% reporting debilitating symptoms). Increasing age, female sex, white ethnicity, poor pre-pandemic general and mental health, overweight/obesity, and asthma were associated with prolonged symptoms in both LS and EHR data, but findings for other factors, such as cardio-metabolic parameters, were inconclusive.